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KMID : 1134819970260010109
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Journal of the Korean Society of Food Science and Nutrition
1997 Volume.26 No. 1 p.109 ~ p.115
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Effect of Methionine Levels on Brain Lipid Peroxidation in Ethanol - treated Rats of Selenium Deficiency
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Cho Soo-Yeul
Lee Mi-Kyung
Park Eun-Mi
Jang Joo-Yeun
Kim Myung-Joo
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Abstract
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This study was designed to investigate the effects of methionine(Met) on the activities of brain lipid peroxidation related enzymes in ethanol administrated rats of selenium(Se) deficiency. Male Sprague-Dawley rats were fed Se deficiency diets containing one of the three levels of Met(0, 3, 9g/㎏ diet) and ethanol(2.5g/㎏ of body weight) was administrated as 25v/v% ethanol treated groups orally. The rats sacrificed after 5 and 10 weeks of feeding periods. Alcohol dehydrogenase activity was increased in ethanol treated groups and was higher Met normal group than Met deficiency and excessive groups at 5 and 10 weeks dieting. Aldehyde dehydrogenase activity was decreased in ethanol treated groups and significantly decreased in Met deficiency group. Monoamine oxidase activity in brain was increased in ethanol treated groups and was predominently increased in Met deficiency groups. Superoxide dismutase and glutathione peroxidase activities were decreased in ethanol treated groups and tended to increase in proportion to level of dietary methionine. Glutathione S-transferase and catalase activities and lipid peroxide content were increased by ethanol administration and were higher Met deficiency group than normal and excessive groups.
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KEYWORD
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methionine, selenium, ethanol, brain lipid peroxidation
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